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CHRISTELLE BOUGOUIN and CHLOE THELCIDE are Interns; FABIENNE CRESPIN-MAILLARD, PH.D., is Research Assistant; CHRISTIAN MAILLARD, PHARM.D., is Director; JEAN MARIE KINOWSKI, PHARM.D., PH.D., is Assistant Director; and MIREILLE FAVIER, PHARM.D., is Assistant Director, Pharmacy Service, Caremeau Hospital Medical Center, Nîmes, France.

Address correspondence to Dr. Favier at the Pharmacy Service, Caremeau Hospital Medical Center, Place du Professeur Debré, Nîmes 3000, France (mireille.favier{at}chu-nimes.fr).

Purpose. The compatibility of ondansetron hydrochloride and methylprednisolone sodium succinate in 5% dextrose injection and 0.9% sodium chloride injection was studied. Methods. Test solutions of ondansetron hydrochloride 0.16 mg/mL and methylprednisolone sodium succinate 2.4 mg/mL were prepared in triplicate and tested in duplicate. Total volumes of 4 and 2 mL of ondansetron hydrochloride solution and methylprednisolone sodium succinate solution, respectively, were added to 50-mL multilayer polyolefin bags containing 5% dextrose injection or 0.9% sodium chloride injection. Bags were stored for 24 hours at 20–25 °C and for 48 hours at 4–8 °C. Chemical compatibility was measured with high-performance liquid chromatography, and physical compatibility was determined visually. Results. Ondansetron hydrochloride was stable for up to 24 hours at 20–25 °C and up to 48 hours at 4–8 °C. Methylprednisolone sodium succinate was stable for up to 48 hours at 4–8 °C. When stored at 20–25 °C, methylprednisolone sodium succinate was stable for up to 7 hours in 5% dextrose injection and up to 24 hours in 0.9% sodium chloride injection. Compatibility data for solutions containing ondansetron hydrochloride plus methylprednisolone sodium succinate revealed that each drug was stable for up to 24 hours at 20–25 °C and up to 48 hours at 4–8 °C. Conclusion. Ondansetron 0.16 mg/mL (as the hydrochloride) and methylprednisolone 2.4 mg/mL (as the sodium succinate) mixed in 50-mL multilayer polyolefin bags were stable in both 5% dextrose injection and 0.9% sodium chloride injection for up to 24 hours at 20–25 °C and up to 48 hours at 4–8 °C. Index terms: Antiemetics; Containers; Dextrose; Diluents; Incompatibilities; Injections; Methylprednisolone sodium succinate; Ondansetron hydrochloride; Polyolefin; Sodium chloride; Stability; Steroids, cortico-; Storage; Temperature