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MALLIK V. ANGALAKUDITI, B.PHARM., PH.D., is Postdoctoral Fellow; KIM C. COLEY, PHARM.D., is Associate Professor; and EDWARD P. KRENZELOK, PHARM.D., is Professor, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA.

Address correspondence to Dr. Angalakuditi at the School of Pharmacy, University of Pittsburgh, 921 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261 (hydmallik02{at}hotmail.com).

Purpose. The patient characteristics, doses taken, and types of exposures in children with acetaminophen-related exposures reported to a regional poison control center (RPCC) were studied. Methods. A retrospective review was conducted of all acetaminophen exposures that occurred between October 31, 2000, and October 31, 2003, in children younger than 18 years who were managed by an RPCC. Children were grouped into three age categories: less than 6 years (group 1), 6–12 years (group 2), and 13–17 years (group 3). Data collected included patient demographics, drug details, type of exposure, time since exposure, exposure site, and caller site. Results. There were 473 exposures to acetaminophen: 76% in group 1, 3% in group 2, and 21% in group 3. Sex was distributed equally among groups, except group 3 was 83% females. The majority of callers seeking information on acetaminophen ingestion in children younger than 12 years were family members (62%), whereas health professionals (61%) were the most common callers for children over 12 years. Unintentional ingestion was the most common type of exposure in group 1 (100%) and group 2 (93.7%). In group 3, intentional ingestions were more common (91%), with females representing far more of these exposures than males (87% versus 14%, respectively). Acetaminophen doses over 200 mg/kg were ingested by 47% of children in group 3. Conclusion. Most acetaminophen exposures reported to an RPCC occurred in children less than six years of age and were unintentional, whereas exposures in children over 12 years were more likely to be intentional overdoses. Index terms: Acetaminophen; Adolescents; Age; Analgesics and antipyretics; Dosage; Pediatrics; Poisoning; Toxicity