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CARY E. JOHNSON, PHARM.D., FASHP, is Professor of Pharmacy, College of Pharmacy, University of Michigan (UM), Ann Arbor, and Clinical Pharmacist—Pediatrics, University of Michigan Hospitals and Health Centers (UMHHC). MARY PETREA COBER, PHARM.D., is. Clinical Pharmacist—Pediatric Surgery, UMHHC, and Clinical Assistant Professor of Pharmacy, College of Pharmacy, UM.

Address correspondence to Dr. Johnson at the College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065 (cejohn{at}umich.edu).

Purpose. The stability of vecuronium bromide 1 mg/mL in preservative-free sterile water for injection for up to 21 days was studied. Methods. A vecuronium bromide 1-mg/mL solution was prepared by diluting 15 vials of 10-mg Vecuronium Bromide for Injection, USP, powder with preservative-free sterile water for injection and adding the solution to an evacuated i.v. bag. Identical 10-mL volumes of the solution were prepared and stored at 23–25 or 3–5 °C in polypropylene syringes. The stability of vecuronium was analyzed in triplicate with stability-indicating high-performance liquid chromatography immediately after preparation of solutions and at 3, 7, 14, and 21 days. The samples were also inspected for volume and color change and for visible precipitation and microbial growth. Results. The percentage of the initial vecuronium bromide concentration remaining at each time point was greater than 100% at both 23–25 and 3–5 °C. There were no detectable changes in volume or color and no precipitation or visible microbial growth. Conclusion. Vecuronium bromide in an extemporaneously prepared solution in preservative-free sterile water for injection was stable for at least 21 days at 23–25 or 3–5 °C. Index terms: Chromatography, liquid; Color; Concentration; Contamination; Diluents; Injections; Polypropylene; Precipitation; Skeletal muscle relaxants; Stability; Storage; Syringes; Temperature; Vecuronium bromide; Volume; Water for Injection