Advertisement
Am J Health-Syst Pharm
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goodin, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goodin, S.

Oral chemotherapeutic agents: Understanding mechanisms of action and drug interactions

Susan Goodin

SUSAN GOODIN, PHARM.D., FCCP, BCOP, is Director, Division of Pharmaceutical Sciences, the Cancer Institute of New Jersey, and Associate Professor of Medicine, the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08901 (goodin{at}umdnj.edu).


Purpose. The mechanisms of action and drug interactions of oral chemotherapeutic agents are reviewed.

Summary. The mechanisms of action, indications, and potential for drug interactions vary for oral chemotherapy. Traditional oral chemotherapy agents cause damage to cancer cells by non-specifically interfering with cellular division. Many of the newer agents have novel targets on cancer cells preferentially, resulting in a different spectrum of toxicity. Since cancer patients are at high risk for drug interactions, usually because of age-related organ dysfunction and the need for concomitant drug therapy for comorbid conditions, understanding these agents and potential for interactions is imperative for all healthcare providers.

Conclusion. Knowledge of the mechanisms and metabolic pathways for the oral chemotherapeutic agents allows the potential to predict possible drug interactions and response while minimizing the risk of adverse outcomes.

Index terms: Antineoplastic agents; Drug administration routes; Drug interactions; Mechanism of action; Metabolism; Neoplasms; Pharmacokinetics; Site of action; Toxicity

 



This article has been cited by other articles:


Home page
JNCI J Natl Cancer InstHome page
R. E. Eilers Jr, M. Gandhi, J. D. Patel, M. F. Mulcahy, M. Agulnik, T. Hensing, and M. E. Lacouture
Dermatologic Infections in Cancer Patients Treated With Epidermal Growth Factor Receptor Inhibitor Therapy
J Natl Cancer Inst, January 6, 2010; 102(1): 47 - 53.
[Abstract] [Full Text] [PDF]


Home page
J Oncol Pharm PractHome page
A. Chan, Y. C. Leow, and M. H. Sim
Patients' perspectives and safe handling of oral anticancer drugs at an Asian cancer center
Journal of Oncology Pharmacy Practice, September 1, 2009; 15(3): 161 - 165.
[Abstract] [PDF]


Home page
The Annals of PharmacotherapyHome page
M. Heung, B. A Mueller, and J. H Segal
Optimizing Anemia Management in Hospitalized Patients with End-Stage Renal Disease
Ann. Pharmacother., February 1, 2009; 43(2): 276 - 282.
[Abstract] [Full Text] [PDF]


Home page
Am J Health Syst PharmHome page
A. L. Erickson, P. M. Szumita, and M. C. Cotugno
Implementation of clinical pharmacy services in a dialysis unit
Am. J. Health Syst. Pharm., November 1, 2008; 65(21): 2011 - 2013.
[Full Text] [PDF]


Home page
Am J Health Syst PharmHome page
M. H. Mahmood, E. P. Armstrong, D. C. Malone, and G. H. Skrepnek
Relationship between pharmaceutical services characteristics and exposure rates to drug-drug interactions in Veterans Affairs medical centers
Am. J. Health Syst. Pharm., September 15, 2008; 65(18): 1744 - 1749.
[Abstract] [Full Text] [PDF]


Home page
Journal of Pharmacy PracticeHome page
S. Tomasello
Anemia of Chronic Kidney Disease
Journal of Pharmacy Practice, June 1, 2008; 21(3): 181 - 195.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Society of Health-System Pharmacists.
Advertisement