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Clinical Reports |
MARIE A. CHISHOLM-BURNS, PHARM.D., MPH, FCCP, FASHP, is Professor and Department Head, Department of Pharmacy Practice and Science, The University of Arizona College of Pharmacy (UACP), Tucson. W. JAQUELINE KWONG, PHARM.D., PH.D., is Director, Worldwide Health Economics and Pricing, Johnson and Johnson Pharmaceutical Services, Raritan, NJ. LAURA L. MULLOY, D.O., FACP, is Professor of Medicine and Chief, Section of Nephrology, Hypertension and Transplantation Medicine, Medical College of Georgia School of Medicine, Augusta. CHRISTINA A. SPIVEY, PH.D., is Research Coordinator, UACP.
Address correspondence to Dr. Chisholm-Burns at the University of Arizona College of Pharmacy, 1295 N. Martin Avenue, P.O. Box 21202, Tucson, AZ 85721 (chisholm{at}pharmacy.arizona.edu).
Methods. Pharmacy refill data were used to measure adherence. In a primary analysis, stepwise regression was used to assess the relationship between independent variables (age, sex, time posttransplant, and race) and adherence. In a secondary analysis to provide categorical summaries, stepwise regression was used to assess the relationship between independent variables (age quartiles, sex, time posttransplant quartiles, and race) and adherence.
Results. In the primary analysis, age and time posttransplant were significant predictors of adherence rate (p < 0.05), with adherence rate decreasing as age and time posttransplant increased. In the secondary analysis, age quartile 4 (
Conclusion. In patients who had received renal transplants, the rate of adherence to immunosuppressant therapy decreased as patient age and time since transplantation increased.
Index terms: Age; Compliance; Immunosuppressive agents; Patients; Race; Sex; Transplantation
Purpose. Relationships between adherence to immunosuppressant therapy and adult renal transplant recipients age, time posttransplant, race, and sex were evaluated to identify factors that predict nonadherence.
60 years) and time posttransplant quartile 1 (
4 years) were significant predictors of adherence (p < 0.01), with adherence rates lower among age quartile 4 and higher among posttransplant quartile 1.
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