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DAVID C. GAMMON, B.S.PHARM., is Clinical Oncology Pharmacist, University of Massachusetts (UMass) Memorial Medical Center, Worcester, and Instructor, Graduate Nursing Program, UMass Medical School, Worcester. KEITH A. REED, PHARM.D., is PH.D. Candidate, Duquesne University, Pittsburgh, PA; at the time of writing, he was a pharmacy student, Massachusetts College of Pharmacy and Health Science (MCPHS), Worcester. MAUSAUM PATEL is a pharmacy student, MCPHS. K. C. BALAJI, M.D., FRCS, is Chief, Division of Urology; Professor of Surgery, Cell Biology and Cancer Biology; and Director, Robotic Surgery and Urologic Research, UMass Memorial Medical Center.

Address correspondence to Mr. Gammon at the Department of Pharmacy, University of Massachusetts Memorial Medical Center, 55 Lake Avenue North, Worcester, MA 01655 (gammond{at}ummhc.org).

Purpose. A new and convenient means of administering fluorouracil and lidocaine for the treatment of intraurethral condyloma acuminata is discussed. Summary. Condyloma acuminata are warts of the genital and perianal region caused by various types of human papillomavirus (HPV). Intraurethral condylomas are associated with complications such as urinary burning, frequency, urgency, urethral bleeding, obstruction, fistula formation, and dyspareunia. A 55-year-old white man had a chief complaint of profuse, but painless, hematuria when he urinated. Cystourethroscopy confirmed extensive intraurethral condylomatous lesions at the external urethral meatus. A biopsy revealed mild squamous dysplasia and cellular changes consistent with HPV infection. A treatment was prepared that included fluorouracil 250 mg combined with 0.18% lidocaine hydrochloride gel. This mixture was given intraurethrally once weekly, and the tip of the penis was clamped immediately after administration using an occlusive penile clamp. The clamp was retained for 10 minutes for the first treatment, 15 minutes for the second, and 20 minutes for the remainder of the treatments. Six treatments were given initially and were well tolerated, although the patient did report occasional pain while urinating and occasional drops of urine. After six weeks of rest, another cycle of six weekly treatments was given. Two weeks after the second course of treatment, one small condyloma was observed in the distal anterior urethra. The urethra was found to be unblocked after three months, and the six-month evaluation revealed no new growth and a clear urethra. Conclusion. Urethral instillation via urethral syringe of fluorouracil injection mixed with lidocaine gel reduced the size and number of a man’s intraurethral condyloma acuminata, allowed cystourethroscopy, and eliminated hematuria. There was no new growth of condyloma acuminata after six months. Index terms: Anesthetics, local; Antineoplastic agents; Condylomata acuminata; Drug administration routes; Fluorouracil; Gels; Lidocaine hydrochloride; Toxicity