HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by McMahon, J. H. Articles by Grayson, M. L. Search for Related Content PubMed PubMed Citation Articles by McMahon, J. H. Articles by Grayson, M. L.

JAMES H. MCMAHON, M.B.B.S., is Infectious Diseases Registrar, Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia. M. LINDSAY GRAYSON, M.B.B.S., M.D., M.SC., FRACP, FAFPHM, is Head of Infectious Diseases, Infectious Diseases Department, Austin Health, and Professor, Department of Medicine, University of Melbourne, Victoria, Australia.

Address correspondence to Dr. McMahon at the Infectious Diseases Department, Austin Health, Studley Road, Heidelberg, Victoria, 3084 Australia (jhmcmahon{at}yahoo.com).

Purpose. A case of torsades de pointes associated with fluconazole use is described. Summary. A 68-year-old woman with a history of hypertension treated with 2.5 mg of indapamide for 16 months sought medical treatment after having two falls 1 month apart. A computed tomography scan and subsequent magnetic resonance imaging of the brain revealed a lesion in the left pons and middle cerebellar peduncle. Biopsy of the pontine lesion revealed large yeast forms and subsequently revealed Cryptococcus neoformans var. gattii. The patient was initially treated with conventional amphotericin B and flucytosine for six weeks. The first week of therapy was complicated by hypokalemia, hypomagnesemia, and an episode of atrial fibrillation that was managed with electrolyte replacement, commencement of metoprolol, and switching from conventional amphotericin B to amphotericin B lipid complex. After six weeks, liposomal amphotericin was discontinued and high-dose oral fluconazole was initiated. Six days after beginning fluconazole therapy, the patient had a generalized tonic–clonic seizure and suffered cardiopulmonary arrest. Postresuscitation, an electrocardiogram demonstrated a corrected Q-T interval of 556 msec. Recurrent episodes of torsades de pointes were also recorded postarrest. Fluconazole was discontinued at this time, and liposomal amphotericin B was resumed. Neurologic and electroencephalographic assessment conducted 48 hours postarrest revealed that significant neurologic damage had been sustained. Supportive care was withdrawn, and the patient died two days later. A postmortem examination revealed no coronary artery disease or hemorrhagic transformation of the pontine cryptococcoma. Conclusion. Treatment with high-dose fluconazole was the probable cause of torsades de pointes in a patient with risk factors for this condition. The benefits and risks of using fluconazole should be carefully weighed for patients with risk factors for Q-T interval prolongation. Index terms: Antifungals; Cryptococcosis; Dosage; Fluconazole; Flucytosine; Geriatrics; Hypokalemia; Metoprolol; Torsades de pointes; Toxicity