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American Journal of Health-System Pharmacy, Vol. 67, Issue 3, 227-230
Copyright © 2010 by American Society of Health-System Pharmacists
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Mixing and compatibility guide for commonly used aerosolized medications

 David K. Burchett, William Darko, James Zahra, John Noviasky, Luke Probst and Adrienne Smith

DAVID K. BURCHETT, PHARM.D., was Pharm.D. Candidate, Albany College of Pharmacy, Albany, NY, at the time of writing. WILLIAM DARKO, PHARM.D., is Assistant Professor of Medicine, Department of Medicine, Section of Clinical Pharmacology, and Adjunct Associate Professor of Pharmacy Practice, Department of Pharmaceutical Care Services; JAMES ZAHRA, B.S.PHARM., is Adjunct Assistant Professor of Pharmacy Practice, Senior Pharmacist, and Intravenous Laboratory Coordinator, Department of Pharmaceutical Care Services; JOHN NOVIASKY, PHARM.D., is Assistant Professor of Medicine, Department of Medicine, Section of Clinical Pharmacology, and Associate Director, Clinical Services and Research, Department of Pharmaceutical Care Services; LUKE PROBST, PHARM.D., BCPS, is Assistant Professor of Medicine, Department of Medicine, Section of Clinical Pharmacology, and Associate Director, Pediatric Clinical Services, Department of Pharmaceutical Care Services; and ADRIENNE SMITH, PHARM.D., BCOP, was Assistant Professor of Medicine, Department of Medicine, Section of Clinical Pharmacology, and Department of Pharmaceutical Care Services, SUNY Upstate Medical University Hospital, Syracuse, at the time of writing

Address correspondence to Dr. Darko at SUNY Upstate Medical University Hospital, 750 East Adams Street, Syracuse, NY 13210 (darkow{at}upstate.edu).


Purpose. A mixing and compatibility guide for commonly used aerosolized medications was developed.

Summary. Compatibility guides for injectable drugs are available as a reference for pharmacists, nurses, and medical personnel. These charts are commonly used in hospitals and other health care institutions and provide a quick, easy reference for compatibility of frequently used intravenous medications. Respiratory therapists are frequently directed to administer various aerosolized medications and are often faced with the challenge of uncertain compatibility of these drugs when mixed together. However, there appear to be limited data regarding the compatibility of these aerosolized admixtures. After a careful review of the literature, a compatibility chart was developed that should provide significant value to pharmacists, nurses, and respiratory therapists who administer aerosolized medications. The authors of a recently published evaluation of the compatibility of common inhalation solutions summarized their findings in a concise table. This table served as a template to develop a more comprehensive mixing and compatibility guide in the form of an easy-to-use reference chart, which includes additional agents, compatibility references on the chart, and compatibility information for pharmacists, nurses, physicians, and respiratory therapists.

Conclusion. A compatibility guide for aerosolized medications was developed for use by staff who administer these agents.

Index terms: Aerosols; Compounding; Guidelines; Incompatibilities; Stability

 

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