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When deciding on the route of administration for antidotal acetylcysteine, the clinician should consider the patient’s susceptibility, the severity of the acetaminophen toxicity, and the elapsed time since ingestion of the overdose.
Effect of Switching Medically Vulnerable Patients with Uncontrolled Diabetes from Isophane Insulin Human to Insulin Glargine
Patients with diabetes who obtained care at an adult medicine clinic run by a county hospital responded similarly to twice-daily basal insulin injections as to a once-daily regimen.
Adverse-Drug-Event Rates for High-Cost and High-Use Drugs in the Intensive Care Unit
Cost alone should not dictate which medications a critical care pharmacist monitors in an intensive care unit, researchers concluded after reviewing nearly four years’ worth of adverse drug events at a large medical center.
Severity and Preventability of Adverse Drug Events Stratified by Medication Cost
No. (%) ADEs
Outcome
High Cost (n = 39)
Low Cost (n = 241)
Severity
Minor interventions needed
10.3
9.1
Moderate interventions needed
53.8
59.3
Immediate life-sustaining treatment or transfer needed
35.9
31.5
Preventability
Preventable error resulting in harm
7.7
8.7
Not preventable
92.3
91.3
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