Table 5

Top 25 Drugs by Expenditures in Nonfederal Hospitals in 2016

Druga2016 Expenditures ($ Thousands)Percent Change From 2015
Infliximab1,093,2964.9
Rituximab1,042,1403.9
Immune globulin904,5319.2
Pegfilgrastim822,185−3.1
Alteplase795,1689.0
Natalizumab738,0054.7
Bevacizumab544,818−11.8
Nivolumab511,128221.4
Daptomycin493,155−4.9
Trastuzumab489,865−3.7
Piperacillin–tazobactam469,3136.5
Influenza virus vaccine421,18716.2
Pneumococcal virus417,787−14.1
Denosumab336,37013.0
Epoetin alfa321,627−1.1
Albumin316,63818.9
Regadenoson300,2390.5
Vasopressin267,926109.9
Filgrastim265,598−16.5
Iohexol245,02713.2
Enoxaparin226,445−19.3
Acetaminophen (i.v. only)225,4293.5
Darbepoetin alfa219,3160.2
Bupivacaine217,7963.0
Iopamidol217,69425.6
  • a For each drug listed, the expenditures shown are the total for brand and generic products and for various dosage forms unless otherwise stated.